Biopsy Pathology of Muscle
Each of these categories goes along with certain diagnostic considerations and pitfalls. Individual biopsy features are only rarely pathognomonic. Establishing a firm diagnosis therefore typically requires integration of all of the biopsy findings and relevant clinical information. With this approach, a muscle biopsy can often provide helpful information in the diagnostic workup of patients presenting with neuromuscular problems.
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Polymyositis and dermatomyositis first of two parts. Pestronk A. Acquired immune and inflammatory myopathies: pathologic classification. Curr Opin Rheumatol. Novel classification of idiopathic inflammatory myopathies based on overlap syndrome features and autoantibodies: analysis of French Canadian patients.
Muscle biopsy - Wikipedia
Redefining dermatomyositis: a description of new diagnostic criteria that differentiate pure dermatomyositis from overlap myositis with dermatomyositis features. Polymyositis: an overdiagnosed entity. Ann Rheum Dis. Integrated diagnosis project for inflammatory myopathies: an association between autoantibodies and muscle pathology. Autoimmun Rev. J Neurol Neurosurg Psychiatry. Anti-Jo-1 antibody-positive patients show a characteristic necrotizing perifascicular myositis. Nuclear actin aggregation is a hallmark of anti-synthetase syndrome-induced dysimmune myopathy.
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A pattern-based approach to the interpretation of skeletal muscle biopsies
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C5b-9 deposits on endomysial capillaries in non-dermatomyositis cases. Chahin N, Engel AG. Acta Neuropathol. Diagnostic value of markers of muscle degeneration in sporadic inclusion body myositis. Acta Myol. Broccolini A, Mirabella M. Hereditary inclusion-body myopathies.
Biochim Biophys Acta. Oculopharyngodistal myopathy is a distinct entity: clinical and genetic features of 47 patients. Rimmed vacuoles in Becker muscular dystrophy have similar features with inclusion myopathies. Facioscapulohumeral muscular dystrophy presenting with unusual phenotypes and atypical morphological features of vacuolar myopathy.
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Pathologic features of muscle in systemic lupus erythematosus: a biopsy series with comparative clinical and immunopathologic observations. Paik JJ. Myopathy in scleroderma and in other connective tissue diseases. Rheumatic and musculoskeletal immune-related adverse events due to immune checkpoint inhibitors: a systematic review of the literature. Arthritis Care Res. A case of myasthenia gravis and myositis induced by nivolumab. Rinsho Shinkeigaku. Focal myositis: a clinicopathologic study of cases of an intramuscular mass-like reactive process.
Am J Surg Pathol. Chronic myopathy associated with anti-signal recognition particle antibodies can be misdiagnosed as facioscapulohumeral muscular dystrophy. J Clin Neuromuscul Dis. Antihydroxymethylglutaryl-coenzyme a reductase necrotizing myopathy masquerading as a muscular dystrophy in a child. A novel autoantibody recognizing kd and kd proteins is associated with an immune-mediated necrotizing myopathy. Arthritis Rheum. Autoantibodies against 3-hydroxymethylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy.
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Embed Size px. Start on. Show related SlideShares at end. WordPress Shortcode. Full Name Comment goes here. Are you sure you want to Yes No. Anchal Tandon. Mohd Hamza. Shubhra Sharma. Show More. No Downloads. Views Total views. Actions Shares. Embeds 0 No embeds. No notes for slide. Muscle biopsy 1. Rashmi Gujarathi 2. High Low 5. Types of muscle fibresTypes of muscle fibres Type - 1 Type -2 Inc. Between These types done byDiff. Dark Intermediate Light Depend on conc. Diseases ass. General abnormalities of muscleGeneral abnormalities of muscle in response to injuryin response to injury Sprouts of remaining sarcoplasm 2.
Satellite cells — more capacity to regenerate. Regenerating fibres — increased basophilia Nuclei increased in number, larger than normal With vesicular chromatin, prominent nuclei. General causes of atrophy non selective - 1. Denervation- MC 2. Disuse 3. Ischemia 4. Aging 5. Poor nutrition. Changes in histochemical profile:Changes in histochemical profile: Denervation Renervation of different Nv.
Causes change in muscle Loss of checkerboard type pattern - Type grouping Motor unit Inflammatory cells invade the endomysium, enveloping necrotic fibres. Sheets of inflamm. Entire wall shows infiltration by inflammatory cells including eosinophils. DM Sarcoidosis-non necrotizing granulomas 2. Idiopathic granulomatous myositis. InflammationInflammation Target Cores Central -pale area: -nce of oxidative enzyme Central-amorphous electron dense material Intermed-Mitochondria Outer- normal Ring fibresRing fibres F Formed by peripheral bundle of myofibril.
Directed circumferentially, encircling inner portion of myofibre. Seen in transverse section.
IBM, distal myopathy, OPD Sarcoplasmic vacuoles Rimmed Vacuole — sharply demarcated vacuole containing granular material that forms red rim in frozen section. Supposed to be autophagic vacuole — membrane bound. Neurogenic atrophyNeurogenic atrophy Diseases affecting lower motor neurons or their axons are- -Amyotrophic lateral sclerosis in adults -Spinal muscular atrophy usually in children -Poliomyelitis - now rare -Peripheral neuropathy of various types Histological changesHistological changes Denervation randomly scattered atrophic fibers Predominantly atrophy of type 2 fibers.
Histological changesHistological changes Denervated muscle fibers Reinnervated by collateral sprouting. DMD Distal myopathyDistal myopathy 1. Welander myopathy 2. Miyoshi myopathy 3. Hereditary variant of IBM 4.